Chemical Synthesis

At Ascentia, we specialize in multi-step syntheses of structurally complex molecules, with extensive experience across a range of synthetic challenges and compound classes.

  • Custom synthesis of structurally complex organic compounds
  • Multi-step synthetic routes
  • Organometallic reactions
  • Asymmetric synthesis
  • Unusual amino acids for solid-phase peptide synthesis (SPPS), including N-alkylated amino acids, β-amino acids, and α,α-disubstituted analogues, amino acids with nonstandard protecting groups
  • Peptidomimetics
  • Aromatic and non-aromatic heterocycles
  • Modified & cyclic peptide synthesis
  • Library synthesis (virtual screening, SAR)
  • Route scouting
  • Synthetic Process Optimization & Route Development
  • Feasibility studies for synthesis scale-up form milligram quantities for early-stage research up to 1-kilogram scale for preclinical studies or compound supply
  • Analytical support, including the identification and synthesis of impurities, degradants, and metabolite reference standards
  • Synthesis of compounds labelled with stable isotopes
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