Organic Synthesis

We specialize in multi-step synthesis of structurally complex molecules, employing a broad spectrum of synthetic methodologies and delivering projects on scales of up to 1 kg. Direct communication with our chemists ensures a thorough understanding of client needs and optimization at every stage of the commissioned work.

We also undertake non-standard projects -our experience enables us to effectively solve complex synthetic challenges that require creative and interdisciplinary approaches.

The pharmacologically relevant chemical space is estimated to encompass 10⁶⁰ molecules. While the synthetically accessible chemical space within our capabilities is naturally smaller, it remains sufficiently broad to address our clients’ needs in the synthesis of:

• Aromatic and non-aromatic heterocycles
• Linear and cyclic peptides
• Modified peptides (e.g., N-methylated peptides, side-chain-modified peptides)
• Solid-phase peptide synthesis (SPPS) products
• Amino acids with non-standard protecting groups
• Stable isotope-labeled compounds
• Compounds with high sp³ carbon content
• Molecules synthesized using organometallic chemistry
• Optically pure compounds (enantiomers and diastereomers)

We also provide support in process development, including:

• Exploration of alternative synthetic routes
• Optimization of reaction conditions
• Process scale-up (from milligrams to kilograms)
• Process efficiency and cost evaluation
• Feasibility studies for synthetic scale-up
• Identification and synthesis of impurities, degradation products, and metabolite standards

Beyond laboratory activities, we offer consulting services in organic synthesis, helping clients efficiently plan, optimize, and execute their chemical projects.

Have questions? Our team will be happy to assist you.
Contact us today at contact@ascentiabio.com.